Sloan-Swartz Center for Theoretical Neurobiology, UCSF
How are episodic memories stored in the hippocampus?
Monday 28th of April 2008 at 03:00pm
The hippocampus is required for the formation of episodic memories.
However, it remains unclear how the different subregions of the
hippocampus (dentate gyrus, CA3, CA1) are involved in memory storage.
I will present a quantitative model to compare different memory
storage strategies. We find that, for the rat, memory storage in the
dentate gyrus (DG) yields the highest storage capacity, especially
when taking into account the birth and death of neurons that only
occur in DG. We therefore propose that plasticity and neurogenesis in
the DG are essential for the stroage of episodic memoryies. I will
discuss the implications of this proposal and contrast it with other
models of memory storage in the hippocampus.
508-20 Evans Hall
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