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Thanos Siapas
Caltech

Hippocampal Network Dynamics and Memory Formation

Wednesday 30th of April 2008 at 12:00pm
508-20 Evans Hall

Many lines of evidence have shown that the hippocampus is critical for the formation of long-term memories, and that this hippocampal involvement is time-limited. The current predominant conjecture is that memories are encoded in the hippocampus during awake behavior and are gradually consolidated across neocortical circuits under the influence of hippocampal activity during sleep. Consistent with this conjecture, the activation modes of hippocampal and cortical circuits are drastically different in the awake and sleep states. In this talk I will characterize hippocampal activity patterns at the network level in different brain states, and discuss how these patterns evolve across time. I will also discuss timing relationships between hippocampal and neocortical activity, and their consequences for the process of memory formation.


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